Description
Product Characteristics: Protein S is a vitamin K-dependent coagulation factor involved in the regulation of the anticoagulant activity of activated protein C. Anti-Protein S antibody clone 7E9 binds to an epitope within the third and fourth EGF-like region of the protein, in a calcium independent manner [1]
Target Information: This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. [provided by RefSeq, Feb 2009]